Our Current Focus
BRAIN-BODY CIRCUITS REGULATING METABOLISM AND APPETITE
Maintaining energy homeostasis requires accurate sensing of incoming nutritional substrates and internal metabolic demands, coupled with mechanisms to direct and utilize available resources. This is orchestrated by a complex interplay of communication between the brain and peripheral organs in the body such as the liver and gut.
Our lab aims to define neural pathways underlying metabolic regulation between peripheral organs and the brain at the molecular, anatomical and functional level. The integrity and alterations of these circuits in mouse models of diet-induced obesity and metabolic syndrome will also be explored. This study will further our understanding of brain communication with peripheral organs and lead to novel strategies for managing metabolic diseases.